Endocrine Abstracts

Purpose: To study the state of the microvasculature and tissue metabolism (according to the dynamics of the FAD and NADH coenzymes) using laser Doppler fluometry (LDF) and laser fluorescence spectroscopy (LFS) in patients with diabetes mellitus.Materials and methods: To implement the combined use of LDF and LFS methods, the Laser Diagnostic Device LAZMA ST was used (registration certificate of Roszdravnadzor No. RZN 2017/5844 of June 08, 2017).<p cla...

Adrenal cortical carcinoma is a rare disease with an incidence of 1–2/million per year. Diagnosis is related to autonomy of adrenal steroid synthesis, tumour size above 6 cm, local invasion and tendency to recurrence. Treatment consists in adrenal surgery, non-specific chemotherapy and radiotherapy, and, more specific-Mitotane (Lysodren).Pathology diagnosis is based on capsular and vascular invasion, histological changes suggestive for malignancy an...

Background: Intravenous bisphosphonates treatment brings real benefits to patients with bone metastases. Unfortunately, this treatment sometimes has a difficult to treat complication, often disabling for the patients – the osteonecrosis of the jaws. A new approach in the management of this complication is the use of platelet rich plasma (PRP).Patients and methods: Five patients aged between 62 and 72 years old (three men and two women) were included...

Objective: To outline the risk factors, the epidemiological profile, and the classification of diabetes type two foot ulcer.Methods: A prospective observational study, including all the people that sought out in a consecutive way, a tertiary diabetic foot service, from February 2002 until September 2012. At admission, the patients were examined and had their ulcers evaluated by only one observer, in accordance with the University of Texas classification....

Pituitary sarcoidosis is a rare form of neurosarcoid, commonly associated with multisystemic sarcoidosis. The most common intracranial site of sarcoidosis leading to endocrine involvement is the hypothalamus and the pituitary gland. The prevalence of hypothalamic–pituitary involvement in multisystemic sarcoiosis is reported to be around 5%.Granulomatous infiltration of the hypothalamus and the pituitary gland always results in endocrine disorder, GH...

Objective: Exogenous and endogenous opioids affect the hypothalamic–pituitary–gonadal axis through binding to receptors centrally and by peripheral inhibition of testosterone synthesis, thereby altering the release of hormones. Approximately 12% of patients with persistent non-cancer pain use strong opioid analgesics in the UK, but the action on endocrine function may not be recognised. The aim of this study is to establish the incidence of gonadotrophin and other en...

Background: Normal pregnancy is a state of physiological oxidative stress (OS) with oxidants facilitating the implantation of the embryo and optimal decidualisation but counterbalanced by antioxidants. Pro-oxidant processes exceeding the anti-oxidants capacity result in imbalanced OS, which has been associated with the ‘’big four’’ obstetric complications: pre-term birth, intra-uterine growth retardation, pre-eclampsia and diabetes gravidarum. Important OS ...

Background: Hypopituitarism is common in patients with pituitary tumors. Still, the influence of pituitary tumor surgery on gonadal function and reproductive health remains underexplored.Objective: a) To assess gonadal function and its impact on quality of life (QoL) in patients with non-functioning pituitary adenomas (NFPA) before and after transsphenoidal surgery (TSS), b) to identify factors that predict recovery of gonadal function following TSS, and...

Introduction: Hybrid closed loop (HCL) systems are made up of continuous glucose monitoring (CGM) sensor, an algorithm that receives the readings from the CGM and an insulin pump able to deliver variable insulin doses according to the information received from the other two parts. Predictive low-glucose suspend (PLGS) insulin pump is able to stop the administration of insulin before hypoglycemia occurs. These new technologies are meant to improve the quality of life and help t...

Background: Bioresorbable screws for surgical fracture treatment are of great interest for the orthopaedic community. Such implants are designed to provide stability and compression of the fracture and should dissolve after healing, thereby making removal of surgical material obsolete. Magnesium implants are a new material option. So far, long-term follow-up of fracture healing and material decay has not been studied in human. Here, we present the results of the 2.5 year follo...